Trifluoroacetic acid → HCID 22623963, compound

HRID 279032Notes

Reaction equation

HRID 279032 reaction equation
C([O:5][N:6]1[C:15](=[O:16])[C:14]2[CH:17]=[C:18]([Cl:21])[C:19]([Cl:20])=[C:12]3[C:13]=2[C:8](=[CH:9][CH:10]=[C:11]3[N:22]2[CH2:26][CH2:25][CH2:24][CH2:23]2)[C:7]1=[O:27])(C)(C)C.C(O)(C(F)(F)F)=O>>[Cl:21][C:18]1[C:19]([Cl:20])=[C:12]2[C:11]([N:22]3[CH2:26][CH2:25][CH2:24][CH2:23]3)=[CH:10][CH:9]=[C:8]3[C:13]2=[C:14]([CH:17]=1)[C:15](=[O:16])[N:6]([OH:5])[C:7]3=[O:27]

Participants

3

Reactant 2

HCID 6422Trifluoroacetic acidHCID 22623898HCID 22623898, compound

Product 1

HCID 22623963HCID 22623963, compoundYield 61.7%

Procedure

A mixture of 2-tert-butyloxy-5,6-dichloro-7-(pyrrolidin-1-yl)-benzo[de]isoquinoline-1,3-dione (50.0 mg, 0.12 mmol, from Example M3-B) and TFA (1.0 mL) was stirred at room temperature for 2 hours and poured into ice water. The solid was washed with water and ether, and dried to give 26 mg of the title compound, mp 200-201 ° C.

Workup

  1. washThe solid was washed with water and ether
  2. customdried

Sources & evidence

ORD record
ord-f401b61bb5b04488b376d61477a85eb2
Source dataset
uspto-grants-2002_03
Patent number
US06362181B1

Reaction notes

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