HCID 22623983, compound → HCID 22624035, compound

HRID 279038Notes

Reaction equation

HRID 279038 reaction equation
C([O:8][N:9]1[C:18](=[O:19])[C:17]2[CH:20]=[C:21]([F:28])[C:22]([N:23]3[CH2:27][CH2:26][CH2:25][CH2:24]3)=[C:15]3[C:16]=2[C:11](=[CH:12][CH:13]=[CH:14]3)[C:10]1=[O:29])C1C=CC=CC=1>[Pd]>[F:28][C:21]1[C:22]([N:23]2[CH2:27][CH2:26][CH2:25][CH2:24]2)=[C:15]2[CH:14]=[CH:13][CH:12]=[C:11]3[C:16]2=[C:17]([CH:20]=1)[C:18](=[O:19])[N:9]([OH:8])[C:10]3=[O:29]

Participants

3

Reactant 1

HCID 22623983HCID 22623983, compound

Product 1

HCID 22624035HCID 22624035, compoundYield 4.6%

Reagents, catalysts & solvents 1

HCID 23938PalladiumCatalyst

Procedure

A solution of 28 mg (0.72 mmol) of 2-benzyloxy-5-fluoro-6-(pyrrolidin-1-yl)-benzo[de]isoquinoline-1,3-dione (from Example Z3) was hydrogenated over 15 mg of 10% Pd/C at room temperature and atmospheric pressure for 2 hours. Pd/C was removed by filtration, and the filtrate was evaporated to yield 10 mg of the title compound, mp 224-226° C.

Workup

  1. customPd/C was removed by filtration
  2. customthe filtrate was evaporated

Sources & evidence

ORD record
ord-9560652bcf7d4781a591ec2d02f2e071
Source dataset
uspto-grants-2002_03
Patent number
US06362181B1

Reaction notes

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