反应详情

温度

50 °C

In 50 mL of anhydrous dimethylformamide were dissolved 2.24 g (6.7 mmol) of methyl 4-bromo-2,2-diphenylbutyrate and 1.30 g (6.7 mmol) of 4-(2-hydroxyphenyl)-4-piperidinol. To the resulting solution was added 1.07 g (10 mmol) of sodium carbonate, followed by stirring under heating at 50° C. for 35 hours. The residue obtained by distilling off the solvent under reduced pressure was dissolved in ethyl acetate, followed by washing with water and drying. The residue obtained by concentrating the solvent under reduced pressure was purified by chromatography on a silica gel column, whereby 870 mg (yield: 29.2%) of methyl 4-(4-hydroxy-4-(2-hydroxyphenyl)piperidino)-2,2-diphenylbutyrate was obtained.

1. customThe residue obtained
2. distillationby distilling off the solvent under reduced pressure
3. dissolutionwas dissolved in ethyl acetate
4. washby washing with water
5. customdrying
6. customThe residue obtained
7. concentrationby concentrating the solvent under reduced pressure
8. customwas purified by chromatography on a silica gel column