Ammonia → HCID 178515461, compound

HRID 279151Notes

Reaction equation

HRID 279151 reaction equation
C[O:2][C:3]1[CH:4]=[CH:5][C:6]2[CH2:7][C:8]3([C:16]4[N:17]=[CH:18][NH:19][CH:20]=4)[CH:13]([C:14]=2[CH:15]=1)[CH2:12][CH2:11][CH2:10][CH2:9]3.Br.N>O>[NH:19]1[CH:20]=[C:16]([C:8]23[CH2:7][C:6]4[CH:5]=[CH:4][C:3]([OH:2])=[CH:15][C:14]=4[CH:13]2[CH2:12][CH2:11][CH2:10][CH2:9]3)[N:17]=[CH:18]1

Participants

5

Reactant 3

HCID 222AmmoniaHCID 260Hydrogen BromideHCID 178487028HCID 178487028, compound

Product 1

HCID 178515461HCID 178515461, compound

Reagents, catalysts & solvents 1

HCID 962WaterSolvent

Procedure

4-(3-Methoxy-4b,5,6,7,8,9-hexahydrofluoren-8a-yl)-1H-imidazole (0.042 g) was mixed with 48% HBr (2 ml) and refluxed for 2 hours. After cooling to the ambient temperature, water (2 ml) was added and the pH was adjusted to 10 with 25% NH3-solution. The precipitated crude product was filtered and washed with water (10 ml). Recrystallisation from methylene chloride/methanol (95:5) gave the pure product. The yield was 0.030 g.

Workup

  1. temperaturerefluxed for 2 hours
  2. additionwas added
  3. customThe precipitated crude product
  4. filtrationwas filtered
  5. washwashed with water (10 ml)
  6. customRecrystallisation from methylene chloride/methanol (95:5)
  7. customgave the pure product

Sources & evidence

ORD record
ord-6538d3edd133441794a5e5e6afee3d53
Source dataset
uspto-grants-2002_03
Patent number
US06362211B1

Reaction notes

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