1-(1-Naphthoyl)-3-(R)-(4-(4-fluorophenyl)piperidinylmethyl)-4-(S)-(cyclopropyl)pyrrolidine → N-Methyl-7-indolinylcarbonyl-3-(R)-(4-(4-fluorophenyl)piperidinylmethyl)-4-(S)-(cyclopropyl)pyrrolidine

HRID 279222Notes

Reaction equation

HRID 279222 reaction equation
[C:1]([C:4]1[CH:5]=[CH:6][CH:7]=[C:8]2[C:12]=1[N:11](C)[CH2:10][CH2:9]2)([OH:3])=O.C1([C:24]([N:26]2[CH2:30][C@@H:29]([CH:31]3[CH2:33][CH2:32]3)[C@H:28]([CH2:34][N:35]3[CH2:40][CH2:39][CH:38]([C:41]4[CH:46]=[CH:45][C:44]([F:47])=[CH:43][CH:42]=4)[CH2:37][CH2:36]3)[CH2:27]2)=O)C2C(=CC=CC=2)C=CC=1>>[CH3:24][N:26]1[CH2:30][C@@H:29]([CH:31]2[CH2:32][CH2:33]2)[C@H:28]([CH2:34][N:35]2[CH2:40][CH2:39][CH:38]([C:41]3[CH:46]=[CH:45][C:44]([F:47])=[CH:43][CH:42]=3)[CH2:37][CH2:36]2)[CH:27]1[C:1]([C:4]1[CH:5]=[CH:6][CH:7]=[C:8]2[C:12]=1[NH:11][CH2:10][CH2:9]2)=[O:3]

Participants

3

Reactant 2

HCID 187135061-(1-Naphthoyl)-3-(R)-(4-(4-fluorophenyl)piperidinylmethyl)-4-(S)-(cyclopropyl)pyrrolidineHCID 226244671-Methylindoline-7-carboxylic acid

Product 1

HCID 86757901N-Methyl-7-indolinylcarbonyl-3-(R)-(4-(4-fluorophenyl)piperidinylmethyl)-4-(S)-(cyclopropyl)pyrrolidine

Procedure

The title compound was prepared from 7-carboxy-N-methylindoline and 3-(S)-(4-(4-fluorophenyl)piperidinylmethyl)-4-(S)-(cyclopropyl)pyrrolidine (Example 9) as described in Example 11. Mass Spectrum (EI) m/e 462 (M+1).

Sources & evidence

ORD record
ord-52700d503d54401ba059e170a95359ed
Source dataset
uspto-grants-2002_03
Patent number
US06362201B1

Reaction notes

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