HuagongsheHuagongshe Chemistry Print Report · For research reference only
1-(1-Naphthoyl)-3-(R)-(4-(4-fluorophenyl)piperidinylmethyl)-4-(S)-(cyclopropyl)pyrrolidine → N-Methyl-7-indolinylcarbonyl-3-(R)-(4-(4-fluorophenyl)piperidinylmethyl)-4-(S)-(cyclopropyl)pyrrolidine
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 1-(1-Naphthoyl)-3-(R)-(4-(4-fluorophenyl)piperidinylmethyl)-4-(S)-(cyclopropyl)pyrrolidine | HCID 18713506 | — |
| Reactant | 1-Methylindoline-7-carboxylic acid | HCID 22624467 | — |
| Product | N-Methyl-7-indolinylcarbonyl-3-(R)-(4-(4-fluorophenyl)piperidinylmethyl)-4-(S)-(cyclopropyl)pyrrolidine | HCID 86757901 | — |
Reaction Steps
The title compound was prepared from 7-carboxy-N-methylindoline and 3-(S)-(4-(4-fluorophenyl)piperidinylmethyl)-4-(S)-(cyclopropyl)pyrrolidine (Example 9) as described in Example 11. Mass Spectrum (EI) m/e 462 (M+1).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06362201B1 |
| Source dataset | uspto-grants-2002_03 |
| ORD ID | ord-52700d503d54401ba059e170a95359ed |
| Source note | uspto-grants-2002_03 |