反应详情

温度

100 °C

To a solution of N-[2-[4-(4-cyanomethylphenyl)-3-cyclohexen-1-yl]propyl 2-propanesulfonamide (see Example 15) in dioxane is added 5 N sodium hydroxide. The mixture is heated to 100° C. for 24 hr. The mixture is then cooled, and acidified with 10% aqueous sodium bisulfate. The mixture is extracted three times with ethyl acetate and the combined organic extracts are dried, filtered and concentrated in vacuo to afford the title compound.

1. temperatureThe mixture is then cooled
2. extractionThe mixture is extracted three times with ethyl acetate
3. customthe combined organic extracts are dried
4. filtrationfiltered
5. concentrationconcentrated in vacuo