2-(5-Chloro-2-benzothienyl)-3-methylbutanoic acid → 3-(4-Fluorobenzyl)-pyrrolylmethyl 2-(5-chloro-2-benzothienyl)-3-methylbutanoate

HRID 27944Notes

Reaction equation

HRID 27944 reaction equation
[Cl:1][C:2]1[CH:3]=[CH:4][C:5]2[S:9][C:8]([CH:10]([CH:14]([CH3:16])[CH3:15])[C:11]([OH:13])=[O:12])=[CH:7][C:6]=2[CH:17]=1.[F:18][C:19]1[CH:32]=[CH:31][C:22]([CH2:23][C:24]2[CH:28]=[CH:27][NH:26][C:25]=2[CH2:29]O)=[CH:21][CH:20]=1>CCOCC>[Cl:1][C:2]1[CH:3]=[CH:4][C:5]2[S:9][C:8]([CH:10]([CH:14]([CH3:15])[CH3:16])[C:11]([O:13][CH2:29][C:25]3[NH:26][CH:27]=[CH:28][C:24]=3[CH2:23][C:22]3[CH:21]=[CH:20][C:19]([F:18])=[CH:32][CH:31]=3)=[O:12])=[CH:7][C:6]=2[CH:17]=1

Participants

4

Reactant 2

HCID 542046732-(5-Chloro-2-benzothienyl)-3-methylbutanoic acidHCID 544646223-(4-Fluorobenzyl)-pyrrolylmethyl alcohol

Product 1

HCID 544191153-(4-Fluorobenzyl)-pyrrolylmethyl 2-(5-chloro-2-benzothienyl)-3-methylbutanoate

Reagents, catalysts & solvents 1

HCID 3283Diethyl EtherSolvent

Procedure

The acid chloride of 2-(5-chloro-2-benzothienyl)-3-methylbutanoic acid is reacted with 3-(4-fluorobenzyl)-pyrrolylmethyl alcohol in ether as in Example 20 to give 3-(4-fluorobenzyl)-pyrrolylmethyl 2-(5-chloro-2-benzothienyl)-3-methylbutanoate.

Sources & evidence

ORD record
ord-b5f20582738f406eb6b3c78ee652cf93
Source dataset
uspto-grants-1980_09
Patent number
US04224330

Reaction notes

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