反应详情

7-Benzyloxy-6-methoxy-4-phenoxyquinazoline (160 mg, 0.44 mmol) in TFA (3 ml) was heated at reflux for 30 minutes. The solvent was removed by evaporation and the residue treated with aqueous sodium hydrogen carbonate solution. The precipitated product was collected by filtration, washed with water and dried to give 7-hydroxy-6-methoxy-4-phenoxyquinazoline (105 mg, 88%).

1. temperatureat reflux for 30 minutes
2. customThe solvent was removed by evaporation
3. additionthe residue treated with aqueous sodium hydrogen carbonate solution
4. filtrationThe precipitated product was collected by filtration
5. washwashed with water
6. customdried