反应详情

A mixture of 4-fluoro-2-methyl-5-nitrophenol (2.1 g, 13 mmol), iron powder (1 g, 18 mmol) and iron(II)sulphate (1.5 g, 10 mmol) in water (40 ml) was refluxed for 4 hours. The reaction mixture was allowed to cool, neutralised with 2M aqueous sodium hydroxide and extracted with ethyl acetate (100 ml). The ethyl acetate extract was dried (MgSO4) and the solvent removed by evaporation to give 2-fluoro-5-hydroxy-4-methylaniline (0.8 g, 47%) as a solid.

1. temperaturewas refluxed for 4 hours
2. temperatureto cool
3. extractionextracted with ethyl acetate (100 ml)
4. extractionThe ethyl acetate extract
5. dry with materialwas dried (MgSO4)
6. customthe solvent removed by evaporation