反应详情

A mixture of 4-chloro-7-(4-pyridylmethoxy)quinazoline hydrochloride (350 mg, 1 mmol) and 2-fluoro-5-hydroxy-4-methylaniline (155 mg, 1.1 mmol), (prepared as described for the starting material in Example 13), in isopropanol (15 ml) was heated at reflux for 1 hour. The resulting precipitate was collected by filtration and purified by reverse phase HPLC using a gradient (0-75%) of methanol in water. Concentrated hydrochloric acid (0.5 ml) was added to the combined fractions of pure product and the solvent was removed by evaporation to give 4-(2-fluoro-5-hydroxy-4-methylanilino)-7-(4-pyridylmethoxy)quinazoline hydrochloride (140 mg, 28%).

1. custom(prepared
2. temperaturewas heated
3. temperatureat reflux for 1 hour
4. filtrationThe resulting precipitate was collected by filtration
5. custompurified by reverse phase HPLC
6. additionConcentrated hydrochloric acid (0.5 ml) was added to the combined fractions of pure product
7. customthe solvent was removed by evaporation