反应详情

A solution of 7-benzyloxy-4-(4-chloro-2-fluorophenoxy)-6-methoxyquinazoline (451 mg, 1.1 mmol) in TFA (4.5 ml) was heated at reflux for 3 hours. The mixture was diluted with toluene and the volatiles removed by evaporation. The residue was triturated with methylene chloride, collected by filtration, washed with ether and dried under vacuum to give 4-(4-chloro-2-fluorophenoxy)-7-hydroxy-6-methoxyquinazoline (320 mg, 90%).

1. temperatureat reflux for 3 hours
2. customthe volatiles removed by evaporation
3. customThe residue was triturated with methylene chloride
4. filtrationcollected by filtration
5. washwashed with ether
6. customdried under vacuum