反应详情

A mixture of 7-benzyloxy-3,4-dihydroquinazolin-4-one (800 mg, 3.17 mmol) and DMF (100 μl) in thionyl chloride (20 ml, 0.27 mmol) was heated at reflux for 3 hours. Excess thionyl chloride was removed by evaporation and the residue azeotroped with toluene and dried under vacuum to give 7-benzyloxy-4-chloroquinazoline hydrochloride (835 mg, 86%) as a cream solid.

1. temperaturewas heated
2. temperatureat reflux for 3 hours
3. customExcess thionyl chloride was removed by evaporation
4. customthe residue azeotroped with toluene
5. customdried under vacuum