反应详情

A mixture of 7-nitro-3,4-dihydroquinazolin-4-one (J. Chem. Soc. 1950, 1104-1111) (5 g, 26 mmol) in thionyl chloride (50 ml) and DMF (1 ml) was heated at reflux for 1.5 hours. Excess thionyl chloride was removed by evaporation and the residue azeotroped with toluene. The residue was suspended in ether, collected by filtration and dried under vacuum to give 4-chloro-7-nitroquinazoline hydrochloride (6.4 g, 100%).

1. temperaturewas heated
2. temperatureat reflux for 1.5 hours
3. customExcess thionyl chloride was removed by evaporation
4. customthe residue azeotroped with toluene
5. filtrationcollected by filtration
6. customdried under vacuum