Ethyl 3-[4-(benzyloxy)phenyl]-2-ethoxyprop-2-enoate → 3-(4-Benzyloxyphenyl)-2-ethoxypropanoic acid ethyl ester

HRID 279681노트

반응식

HRID 279681 반응식
[CH2:1]([O:3][C:4](=[O:24])[C:5]([O:21][CH2:22][CH3:23])=[CH:6][C:7]1[CH:12]=[CH:11][C:10]([O:13][CH2:14][C:15]2[CH:20]=[CH:19][CH:18]=[CH:17][CH:16]=2)=[CH:9][CH:8]=1)[CH3:2]>CO.[Rh]>[CH2:1]([O:3][C:4](=[O:24])[CH:5]([O:21][CH2:22][CH3:23])[CH2:6][C:7]1[CH:12]=[CH:11][C:10]([O:13][CH2:14][C:15]2[CH:16]=[CH:17][CH:18]=[CH:19][CH:20]=2)=[CH:9][CH:8]=1)[CH3:2]

참가 물질

4

반응물 1

HCID 54423854Ethyl 3-[4-(benzyloxy)phenyl]-2-ethoxyprop-2-enoate

생성물 1

HCID 110779683-(4-Benzyloxyphenyl)-2-ethoxypropanoic acid ethyl ester수율 10%

시약·촉매·용매 2

HCID 23948Rhodium촉매HCID 887Methanol용매

실험 절차

3-(4-Benzyloxyphenyl)-2-ethoxyacrylic acid ethyl ester (described in Example 1a) (0.5 g; 1.5 mole) was hydrogenated at atmospheric pressure using rhodium on charcoal as catalyst (5%, 50 mg) in methanol (20 ml). The crude product was purified by chromatography using heptane:ethyl acetate (5:1) as eluent to give 50 mg (yield 10%) of 3-(4-benzyloxyphenyl)-2-ethoxypropanoic acid ethyl ester.

후처리

  1. customThe crude product was purified by chromatography

출처 및 근거

ORD 기록
ord-f149f959546b4e9bbc8a1912cd5efd74
출처 데이터셋
uspto-grants-2002_03
특허 번호
US06362360B1

반응 노트

불러오는 중…