Hydrochloric Acid → HCID 54529230, compound

HRID 279702Notes

Reaction equation

HRID 279702 reaction equation
C[O:2][C:3]([C:5]1[CH:10]=[CH:9][CH:8]=[CH:7][C:6]=1[S:11]([N:14]1[CH2:32][CH2:31][CH2:30][C@H:15]1[C:16]([NH:18][C@H:19]([C:27]([OH:29])=[O:28])[CH2:20][C:21]1[CH:26]=[CH:25][CH:24]=[CH:23][CH:22]=1)=[O:17])(=[O:13])=[O:12])=[O:4].[OH-].[Na+].Cl>O1CCOCC1>[C:3]([C:5]1[CH:10]=[CH:9][CH:8]=[CH:7][C:6]=1[S:11]([N:14]1[CH2:32][CH2:31][CH2:30][C@H:15]1[C:16]([NH:18][C@H:19]([C:27]([OH:29])=[O:28])[CH2:20][C:21]1[CH:22]=[CH:23][CH:24]=[CH:25][CH:26]=1)=[O:17])(=[O:13])=[O:12])([OH:4])=[O:2]

Participants

5

Reactant 3

HCID 313Hydrochloric AcidHCID 14798Sodium HydroxideHCID 53805764HCID 53805764, compound

Product 1

HCID 54529230HCID 54529230, compound

Reagents, catalysts & solvents 1

HCID 312751,4-DioxaneSolvent

Procedure

The product of Example 18 (56) (1.8 mmoles) was mixed with dioxane (25 mL) and 1N NaOH (1.8 mmoles) and the reaction was stirred at room temperature for 16 hours. 1N HCl (1.8 mmoles) was added and the water and dioxane were removed under reduced pressure. The product was extracted with 0.2 N NaOH (50 mL) and EtOAc (2×50 mL) and the recovered organic layer was dried over MgSO4, filtered, and concentrated to yield a colorless oil.

Workup

  1. customthe water and dioxane were removed under reduced pressure
  2. extractionThe product was extracted with 0.2 N NaOH (50 mL) and EtOAc (2×50 mL)
  3. dry with materialthe recovered organic layer was dried over MgSO4
  4. filtrationfiltered
  5. concentrationconcentrated
  6. customto yield a colorless oil

Sources & evidence

ORD record
ord-2ace3058615d435caa1dfc883f5846be
Source dataset
uspto-grants-2002_03
Patent number
US06362341B1

Reaction notes

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