HuagongsheHuagongshe Chemistry Print Report · For research reference only
Lithium Hydroxide → N-(Toluene4-sulfonyl)-L-prolyl-L-tryptophan
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Lithium Hydroxide | HCID 3939 | — |
| Reactant | Methyl tryptophanate hydrochloride | HCID 2734891 | — |
| Reactant | N-tosyl-(s)-proline monohydrate | HCID 69463844 | — |
| Solvent | Oxolane--water (1/1) | HCID 21881883 | — |
| Product | N-(Toluene4-sulfonyl)-L-prolyl-L-tryptophan | HCID 54463657 | — |
Reaction Steps
N-(Toluene-4-sulfonyl)-L-proline hydrate was coupled to L-tryptophan methyl ester hydrochloride using the procedure described in Method 3. The title compound was prepared via hydrolysis of the methyl ester using LiOH in THF/water.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06362341B1 |
| Source dataset | uspto-grants-2002_03 |
| ORD ID | ord-bf80eb28e220475ca19f0db4d3973291 |
| Source note | uspto-grants-2002_03 |