Pyridinium chloride → 4-(3-Chloro-5-(trifluoromethyl)pyridin-2-yl)oxyphenol

HRID 279740Notes

Reaction equation

HRID 279740 reaction equation
[Cl:1][C:2]1[C:3]([O:12][C:13]2[CH:18]=[CH:17][C:16]([O:19]C)=[CH:15][CH:14]=2)=[N:4][CH:5]=[C:6]([C:8]([F:11])([F:10])[F:9])[CH:7]=1.Cl.N1C=CC=CC=1>Cl>[Cl:1][C:2]1[C:3]([O:12][C:13]2[CH:18]=[CH:17][C:16]([OH:19])=[CH:15][CH:14]=2)=[N:4][CH:5]=[C:6]([C:8]([F:11])([F:9])[F:10])[CH:7]=1

Participants

4

Reactant 2

HCID 10176127Pyridinium chlorideHCID 19986019HCID 19986019, compound

Product 1

HCID 97959974-(3-Chloro-5-(trifluoromethyl)pyridin-2-yl)oxyphenol

Reagents, catalysts & solvents 1

HCID 313Hydrochloric AcidSolvent

Procedure

The product from (e) (2 g) was heated with pyridine hydrochloride (20 g) at 170°-180° C. for 6 hours. The mixture was cooled, diluted with dilute hydrochloric acid, and extracted with ether. The ether extracts gave an oily solid which was purified by preparative thin layer chromatography using silica as the adsorbent and 6% ethanol-chloroform as the solvent.

Workup

  1. temperatureThe mixture was cooled
  2. extractionextracted with ether
  3. customThe ether extracts gave an oily solid which
  4. customwas purified by preparative thin layer chromatography

Sources & evidence

ORD record
ord-8a94ecfd6c664e179841df2615ec269d
Source dataset
uspto-grants-1986_05
Patent number
US04586953

Reaction notes

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