反应详情

5 g of adenosine-5'-carboxylic acid methyl ester are heated together with 100 ml of tert.-butylamine on a streambath until a clear solution is obtained and thereafter the reaction mixture is left to stand for 16 hours at ambient temperature. Excess tert.-butylamine is then distilled off and the residue is mixed with methanol, again evaporated to dryness and the solid residue, after slurrying in cold methanol is filtered off with suction. After recrystallizing twice from a little methanol, there are obtained 2.15 g (38% of theory) of adenosine-5'-carboxylic acid N-tert.-butylamide, which melts, with decomposition, at 279°-280° C.

1. customis obtained
2. waitthe reaction mixture is left
3. distillationExcess tert.-butylamine is then distilled off
4. additionthe residue is mixed with methanol
5. customagain evaporated to dryness
6. filtrationis filtered off with suction
7. customAfter recrystallizing twice from a little methanol, there