Hydrochloric Acid → Ethyl p-(ethoxycarbonylmethoxy)benzimidate hydrochloride

HRID 279862Notes

Reaction equation

HRID 279862 reaction equation
[ClH:1].[C:2]([C:4]1[CH:16]=[CH:15][C:7]([O:8][CH2:9][C:10]([O:12][CH2:13][CH3:14])=[O:11])=[CH:6][CH:5]=1)#[N:3].[CH2:17]([O:19]CC)[CH3:18]>C(O)C>[ClH:1].[CH2:13]([O:12][C:10]([CH2:9][O:8][C:7]1[CH:15]=[CH:16][C:4]([C:2](=[NH:3])[O:19][CH2:17][CH3:18])=[CH:5][CH:6]=1)=[O:11])[CH3:14]

Participants

5

Reactant 3

HCID 313Hydrochloric Acid2×HCID 3283Diethyl EtherHCID 207426Ethyl (4-cyanophenoxy)acetate

Product 1

HCID 12222276Ethyl p-(ethoxycarbonylmethoxy)benzimidate hydrochloride

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

Dry hydrogen chloride was passed through a mixture of ethyl 2-p-cyanophenoxyacetate (30.75 g.), diethyl ether (500 ml.) and ethanol (10 ml.) at 0°-5° C. until the solution was saturated with hydrogen chloride, and the mixture was kept at 0° C. for 3 days and then filtered. There was thus obtained as solid residue ethyl p-(ethoxycarbonylmethoxy)benzimidate hydrochloride,

Workup

  1. filtrationfiltered

Sources & evidence

ORD record
ord-6167dfc7c3f44422a2aa5b534a52532d
Source dataset
uspto-grants-1986_05
Patent number
US04587246

Reaction notes

Loading…