HCID 15068624, compound → HCID 20252039, compound

HRID 279870Notes

Reaction equation

HRID 279870 reaction equation
C(OC([N:11]1[CH2:16][CH:15]2[CH2:17][C:18]([Cl:21])([C:19]#[N:20])[CH:12]1[CH:13]=[CH:14]2)=O)C1C=CC=CC=1.C(O)(=O)C.[BrH:26]>C(O)(=O)C>[BrH:26].[Cl:21][C:18]1([C:19]#[N:20])[CH2:17][CH:15]2[CH:14]=[CH:13][CH:12]1[NH:11][CH2:16]2

Participants

4

Reactant 2

HCID 15068624HCID 15068624, compoundHCID 21893785Acetic Acid Mixture with Hydrobromic Acid

Product 1

HCID 20252039HCID 20252039, compound

Reagents, catalysts & solvents 1

HCID 176Acetic AcidSolvent

Procedure

5.0 g. (0.0165 moles) of N-benzyloxycarbonyl-7-chloro-7-cyano-2-azabicyclo[2.2.2]oct-5-ene are dissolved in a mixture of 30 ml. of glacial acetic acid and 15 ml. of a 4-5N glacial acetic acid/hydrogen bromide mixture. The reaction mixture is allowed to stand at room temperature for 10 minutes, and is then evaporated. The evaporation residue is crystallized from acetone.

Workup

  1. customis then evaporated
  2. customThe evaporation residue is crystallized from acetone

Sources & evidence

ORD record
ord-e31874ef70ca481ba196f82b5c642d33
Source dataset
uspto-grants-1986_05
Patent number
US04587251

Reaction notes

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