反应详情

Add dropwise 3.9 gm of ethyl bromopyruvate in 50 ml of ethanol to a flask containing 3.46 gm of benzyliminocyclopentane and 2.0 g of triethylamine in 50 ml of ethanol at 0° C., stir for 2 hours, then heat to reflux for 2 hours. Concentrate the reaction mixture and partition between 1N HCl and ether. Dry the ether extract over magnesium sulfate, filter, concentrate under high vacuum to obtain a brown oil and distill in a kugelrohr at 190°-210°/0.1 mm to obtain the title compound of Part A as a yellow oil.

1. temperatureheat
2. temperatureto reflux for 2 hours
3. concentrationConcentrate the reaction mixture
4. custompartition between 1N HCl and ether
5. dry with materialDry the ether
6. extractionextract over magnesium sulfate
7. filtrationfilter
8. concentrationconcentrate under high vacuum
9. customto obtain a brown oil
10. distillationdistill in a kugelrohr at 190°-210°/0.1 mm