Guanidine Hydrochloride → HCID 23323052, compound

Participants

Reaction Steps

The aldehyde from above was converted to 2-(5,6,7-trimethoxy-2-naphthylmethyl)-3-anilinoacrylonitrile on a 8 mmol scale in the same manner as Example 5-A. The crude product from this reaction was cyclised with guanidine hydrochloride and sodium methylate in ethanol as in Example 5-B to give the title compound as the free base, 0.74 g (27% yield). This was recrystallised from ethanol plus an equivalent of hydrochloric acid, 0.26 g, mp 252°-254°. Anal. Calcd. for C18H20N4O3HCl: C 57.37; H, 5.62; N, 14.87; Cl, 9.41. Found: C, 57.11; H, 5.67; N, 14.79; Cl, 9.31.

Provenance & Evidence