反应详情

3-Bromofuran (20 g) was added to a solution of n-butyllithium (2.5M in hexanes, 60 ml) in diethyl ether (200 ml) at -70° C. After 30 minutes, ethyl trifluoroacetate (28.6 g) was added slowly. After a further 1 hour the mixture was allowed to warm to room temperature and was then left to stir overnight. 1M Hydrochloric acid (100 ml) was added and the mixture stirred for 5 minutes. The organic layer was separated, washed, dried and evaporated. The residue was distilled to give the title compound. B.p. 118° C.

1. waitAfter a further 1 hour the mixture was allowed
2. waitwas then left
3. stirringthe mixture stirred for 5 minutes
4. customThe organic layer was separated
5. washwashed
6. customdried
7. customevaporated
8. distillationThe residue was distilled