Dimethylamine → HCID 13344548, compound

HRID 280074Notes

Reaction equation

HRID 280074 reaction equation
[Cl:1][C:2]1[CH:16]=[C:15]([N:17]=[C:18]=[O:19])[CH:14]=[CH:13][C:3]=1[C:4]([O:6]C1CCCCC1)=[S:5].[CH3:20][NH:21][CH3:22]>C1(C)C=CC=CC=1>[Cl:1][C:2]1[CH:16]=[C:15]([NH:17][C:18]([N:21]([CH3:22])[CH3:20])=[O:19])[CH:14]=[CH:13][C:3]=1[C:4]([S:6][CH:2]1[CH2:16][CH2:15][CH2:14][CH2:13][CH2:3]1)=[O:5]

Participants

4

Reactant 2

HCID 674DimethylamineHCID 53771984HCID 53771984, compound

Product 1

HCID 13344548HCID 13344548, compound

Reagents, catalysts & solvents 1

HCID 1140TolueneSolvent

Procedure

20 g of cyclohexyl 2-chloro-4-isocyanatothiobenzoate in 80 ml of toluene were added dropwise to excess aqueous dimethylamine solution at room temperature. The mixture was kept at room temperature, stirred overnight and then filtered under suction. 16.3 g of N-(3-chloro-4-cyclohexylmercaptocarbonylphenyl)-N',N'-dimethylurea (compound no. 35) were obtained.

Workup

  1. customwas kept at room temperature
  2. filtrationfiltered under suction

Sources & evidence

ORD record
ord-0ab456e5b979449c90641974acd8c05b
Source dataset
uspto-grants-1986_05
Patent number
US04588434

Reaction notes

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