Thioglycolic Acid → HCID 23321718, compound

HRID 280091Notes

Reaction equation

HRID 280091 reaction equation
Cl[CH2:2][CH2:3][CH2:4][CH2:5][CH2:6][CH2:7][OH:8].[SH:9][CH2:10][C:11]([OH:13])=[O:12]>[OH-].[Na+]>[C:11]([CH2:10][S:9][CH2:2][CH2:3][CH2:4][CH2:5][CH2:6][CH2:7][OH:8])([OH:13])=[O:12]

Participants

4

Reactant 2

HCID 1133Thioglycolic AcidHCID 748286-Chloro-1-hexanol

Product 1

HCID 23321718HCID 23321718, compound

Reagents, catalysts & solvents 1

HCID 14798Sodium HydroxideSolvent

Conditions

Temperature
50 °C

Procedure

4.5 ml (0.04M) of 6-chloro-1-hexanol is added to a solution of 2.8 ml (0.04M) of mercaptoacetic acid in 120 ml of 1N NaOH. The solution is warmed to about 50° C. for 16 hours, then acidified and extracted repeatedly with ethyl acetate. The combined extracts are concentrated to dryness and the residue purified by recrystallization.

Workup

  1. extractionextracted repeatedly with ethyl acetate
  2. concentrationThe combined extracts are concentrated to dryness
  3. customthe residue purified by recrystallization

Sources & evidence

ORD record
ord-dbb7efea8cf44cce95e82cf72506bc37
Source dataset
uspto-grants-1986_05
Patent number
US04588718

Reaction notes

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