Triethylamine → HCID 13478097、化合物

HRID 280096ノート

反応式

HRID 280096 の反応式
Cl[C:2]1[N:11]=[CH:10][C:9]2[C:4](=[CH:5][CH:6]=[CH:7][CH:8]=2)[N:3]=1.[F:12][C:13]1[CH:28]=[CH:27][C:16]([O:17][CH2:18][CH2:19][CH2:20][N:21]2[CH2:26][CH2:25][NH:24][CH2:23][CH2:22]2)=[CH:15][CH:14]=1.C(N(CC)CC)C>C(O)(C)C>[F:12][C:13]1[CH:14]=[CH:15][C:16]([O:17][CH2:18][CH2:19][CH2:20][N:21]2[CH2:22][CH2:23][N:24]([C:2]3[N:11]=[CH:10][C:9]4[C:4](=[CH:5][CH:6]=[CH:7][CH:8]=4)[N:3]=3)[CH2:25][CH2:26]2)=[CH:27][CH:28]=1

参加物

5

反応物 3

HCID 8471TriethylamineHCID 740542-ChloroquinazolineHCID 18733961-[3-(4-Fluorophenoxy)propyl]piperazine

生成物 1

HCID 13478097HCID 13478097、化合物

試薬・触媒・溶媒 1

HCID 3776Isopropanol溶媒

実験手順

2.5 g 2-Chloro-quinazoline, 3.8 g 1-[3-(4-fluorophenoxy)propyl]piperazine and 2.5 ml triethylamine in 15 ml isopropanol are stirred under reflux for 5 hours. The solvent is then evaporated in vacuo and the residue partitioned between water and methylene chloride. The organic phase is dried and evaporated. The residue is recrystallized from ethanol to yield the title compound, m.p. 126°-128° C.

後処理

  1. temperatureunder reflux for 5 hours
  2. customThe solvent is then evaporated in vacuo
  3. customthe residue partitioned between water and methylene chloride
  4. customThe organic phase is dried
  5. customevaporated
  6. customThe residue is recrystallized from ethanol

出典と根拠

ORDレコード
ord-87f2de8023f14f53ac1b7ff2295fa747
出典データセット
uspto-grants-1986_05
特許番号
US04588725

反応ノート

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