HRID280102

反应详情

EQUATION

反应方程式

HRID 280102 的结构方程式

AUXILIARIES

试剂、催化剂与溶剂

1

PROCEDURE

实验过程

21.2 g of sodium fluoride are added to a solution of 107.8 g of ethyl 2-(2,3,4,5-tetrafluorobenzoyl)-3-cyclopropylaminoacrylate in 400 ml of anhydrous dimethylformamide. The reaction mixture is then stirred under reflux for 2 hours and, while hot, poured onto ice. The precipitate is filtered off with suction, thoroughly washed with water and dried over calcium chloride at 100° C. in vacuo. 91.2 g of ethyl 1-cyclopropyl-6,7,8-trifluoro-1,4-dihydro-4-oxo-3-quinolinecarboxylate of melting point 167°-168° C. are obtained.

WORKUP

后处理

  1. temperatureunder reflux for 2 hours
  2. additionwhile hot, poured onto ice
  3. filtrationThe precipitate is filtered off with suction
  4. washthoroughly washed with water
  5. dry with materialdried over calcium chloride at 100° C. in vacuo