Hydrogen Bromide → HCID 13653512, compound

HRID 280133Notes

Reaction equation

HRID 280133 reaction equation
[CH3:1][N:2]([N:14]1[CH:18]=[CH:17][CH:16]=[C:15]1[C:19](=[O:27])[C:20]1[CH:25]=[CH:24][CH:23]=[CH:22][C:21]=1[F:26])[C:3](=[O:13])[CH2:4][NH:5]C(OC(C)(C)C)=O.[BrH:28]>CO>[BrH:28].[CH3:1][N:2]([N:14]1[CH:18]=[CH:17][CH:16]=[C:15]1[C:19](=[O:27])[C:20]1[CH:25]=[CH:24][CH:23]=[CH:22][C:21]=1[F:26])[C:3](=[O:13])[CH2:4][NH2:5]

Participants

4

Reactant 2

HCID 260Hydrogen BromideHCID 13653510HCID 13653510, compound

Product 1

HCID 13653512HCID 13653512, compoundYield 95%

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

A slurry prepared from 1-[N-methyl-(t-butoxycarbonylamino)acetamido]-2-(2-fluorobenzoyl)pyrrole (20 g, 53.2 mmol) and 100 ml of methanol solution containing 12 ml of 48% HBr (0.106 mol) was stirred at room temperature for 6 hours. The resultant solution was evaporated to a solid which was recrystallized from isopropanol-ether to give 18 g (95%) of powder.

Workup

  1. customThe resultant solution was evaporated to a solid which
  2. customwas recrystallized from isopropanol-ether

Sources & evidence

ORD record
ord-5a18e76085664bf98c6d03ebecd7ce35
Source dataset
uspto-grants-1986_05
Patent number
US04588727

Reaction notes

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