Piperidine → HCID 13799024, compound

HRID 280164Notes

Reaction equation

HRID 280164 reaction equation
S(O)(=O)(=O)C.[CH3:6][O:7][C:8]1[CH:9]=[C:10]2[CH:13]([CH2:14]O)[CH2:12][C:11]2=[CH:16][CH:17]=1.[NH:18]1[CH2:23][CH2:22][CH2:21][CH2:20][CH2:19]1>C1(C)C=CC=CC=1>[CH3:6][O:7][C:8]1[CH:9]=[C:10]2[CH:13]([CH2:14][N:18]3[CH2:23][CH2:22][CH2:21][CH2:20][CH2:19]3)[CH2:12][C:11]2=[CH:16][CH:17]=1

Participants

4

Reactant 2

HCID 8082PiperidineHCID 131714665HCID 131714665, compound

Product 1

HCID 13799024HCID 13799024, compound

Reagents, catalysts & solvents 1

HCID 1140TolueneSolvent

Procedure

A solution of 5-methoxy-1-hydroxymethylbenzocyclobutene mesylate (38 g) and piperidine (45 ml) in toluene (180 ml) is refluxed under nitrogen for about 12 hours. The reaction mixture is filtered and the filtrate is evaporated in vacuo leaving a liquid residue which is used without further purification in the next step.

Workup

  1. filtrationThe reaction mixture is filtered
  2. customthe filtrate is evaporated in vacuo
  3. customleaving a liquid residue which
  4. customis used without further purification in the next step

Sources & evidence

ORD record
ord-9ababd5269564b0baf941e88201181cf
Source dataset
uspto-grants-1986_05
Patent number
US04588719

Reaction notes

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