Triethylamine → HCID 131714667, compound

HRID 280167Notes

Reaction equation

HRID 280167 reaction equation
[CH3:1][S:2](Cl)(=[O:4])=[O:3].[Cl:6][CH2:7][CH2:8][CH2:9][O:10][C:11]12[CH:20]=[CH:19][CH:18]=[CH:17][CH:12]1[CH2:13][CH:14]2[CH2:15][OH:16].C(N(CC)CC)C>C(Cl)Cl>[S:2]([OH:4])(=[O:10])(=[O:3])[CH3:1].[Cl:6][CH2:7][CH2:8][CH2:9][O:10][C:11]12[CH:20]=[CH:19][CH:18]=[CH:17][CH:12]1[CH2:13][CH:14]2[CH2:15][OH:16]

Participants

5

Reactant 3

HCID 8471TriethylamineHCID 31297Methanesulfonyl chlorideHCID 131714668HCID 131714668, compound

Product 1

HCID 131714667HCID 131714667, compound

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Procedure

Methane sulfonylchloride (1.13 g) is added dropwise to a stirred solution of 3-(3-chloropropoxy)-1-hydroxymethylbenzocyclobutene (1.83 g) and triethylamine (1.58 ml) in methylene chloride (32 ml) at 5° C. under nitrogen. The reaction mixture is stirred at RT for about 2 hours, washed with water, saturated NaCl, dried over Na2SO4, filtered and evaporated in vacuo yielding the desired product as an oil.

Workup

  1. washwashed with water, saturated NaCl
  2. dry with materialdried over Na2SO4
  3. filtrationfiltered
  4. customevaporated in vacuo

Sources & evidence

ORD record
ord-4100b5bcbe6a4019a04dd33b99a79ea6
Source dataset
uspto-grants-1986_05
Patent number
US04588719

Reaction notes

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