反应详情

Potassium cyanide (11.18 g) and dibenzo-18-crown-6(1.0 g) are added to a solution of 5-[p-(chloromethyl)phenethyl]imidazo[1,5-a]pyridine (9.5 g) in 300 ml of dry acetonitrile under nitrogen. The mixture is refluxed for 24 hours, the solvent is evaporated and the residue partitioned between methylene chloride and water. The organic phase is separated, dried and evaporated to yield 5-[p-(cyanomethyl)phenethyl]imidazo[1,5-a]pyridine.

1. temperatureThe mixture is refluxed for 24 hours
2. customthe solvent is evaporated
3. customthe residue partitioned between methylene chloride and water
4. customThe organic phase is separated
5. customdried
6. customevaporated