Sodium Bicarbonate → HCID 13135501, compound

Participants

Reaction Steps

2-(1-imidazolyl)-3,4-dihydro-6-hydroxy-1(2H)-naphthalenone hydrobromide (1.35 g) was dissolved in water. The solution, basified with NaHCO3, extracted with CH2Cl2, dried and evaporated, gave 1.15 g of 2-(1-imidazolyl)-3,4-dihydro-6-hydroxy-1(2H)-naphthalenone. By proceeding analogously all the compounds reported in Example 12 were obtained as free bases, in particular, for example, 2-(1-imidazolyl)-3,4-dihydro-5-bromo-6-hydroxy-1(2H)-naphthalenone.

Provenance & Evidence