Sodium Bicarbonate → HCID 13135501, compound

HRID 280286Notes

Reaction equation

HRID 280286 reaction equation
Br.[N:2]1([CH:7]2[CH2:16][CH2:15][C:14]3[C:9](=[CH:10][CH:11]=[C:12]([OH:17])[CH:13]=3)[C:8]2=[O:18])[CH:6]=[CH:5][N:4]=[CH:3]1.C([O-])(O)=O.[Na+]>O>[N:2]1([CH:7]2[CH2:16][CH2:15][C:14]3[C:9](=[CH:10][CH:11]=[C:12]([OH:17])[CH:13]=3)[C:8]2=[O:18])[CH:6]=[CH:5][N:4]=[CH:3]1

Participants

4

Reactant 2

HCID 516892Sodium BicarbonateHCID 13135502HCID 13135502, compound

Product 1

HCID 13135501HCID 13135501, compoundYield 115.4%

Reagents, catalysts & solvents 1

HCID 962WaterSolvent

Procedure

2-(1-imidazolyl)-3,4-dihydro-6-hydroxy-1(2H)-naphthalenone hydrobromide (1.35 g) was dissolved in water. The solution, basified with NaHCO3, extracted with CH2Cl2, dried and evaporated, gave 1.15 g of 2-(1-imidazolyl)-3,4-dihydro-6-hydroxy-1(2H)-naphthalenone. By proceeding analogously all the compounds reported in Example 12 were obtained as free bases, in particular, for example, 2-(1-imidazolyl)-3,4-dihydro-5-bromo-6-hydroxy-1(2H)-naphthalenone.

Workup

  1. extractionextracted with CH2Cl2
  2. customdried
  3. customevaporated

Sources & evidence

ORD record
ord-d2ea2864815546838543ebda690dc59b
Source dataset
uspto-grants-1986_05
Patent number
US04588738

Reaction notes

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