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2-Amino-1-[3-(trifluoromethyl)phenyl]ethan-1-ol → N-(3-(4-Methylphenyl)propyl)-2-hydroxy-2-(3-trifluoromethylphenyl)ethanamine
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | 2-Amino-1-[3-(trifluoromethyl)phenyl]ethan-1-ol | HCID 30514 | — |
| 反応物 | 1-(4-Methylphenyl)propan-2-one | HCID 137428 | — |
| 反応物 | 4-(p-Tolyl)-2-butanone | HCID 5463908 | — |
| 生成物 | N-(3-(4-Methylphenyl)propyl)-2-hydroxy-2-(3-trifluoromethylphenyl)ethanamine | HCID 23322159 | — |
反応手順
The title compound was prepared in the manner described in Example 3, replacing 2-(3-chlorophenyl)-2-hydroxy ethanamine by 2-(3-trifluoromethylphenyl)-2-hydroxyethanamine, and 4-methylphenylacetone by 4-(4-methylphenyl)butan-2-one. The chromatographed material was recrystallised from hexane to give the title compound mp 52°-55° as a 44:56 ratio of diastereoisomers.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US04588749 |
| 出典データセット | uspto-grants-1986_05 |
| ORD ID | ord-cbacb4e120714d02b99b497a1b78102c |
| 出典メモ | uspto-grants-1986_05 |