2-(3-Chlorophenyl)-2-oxoacetaldehyde → N-(3-(4-Methylphenyl)propyl)-2-hydroxy-2-(3-chlorophenyl)ethanamine

HRID 280309Notes

Reaction equation

HRID 280309 reaction equation
[Cl:1][C:2]1[CH:3]=[C:4]([C:8]([CH:10]=O)=[O:9])[CH:5]=[CH:6][CH:7]=1.[CH3:12][C:13]1[CH:18]=[CH:17][C:16]([CH2:19][CH2:20][CH2:21][NH2:22])=[CH:15][CH:14]=1>>[CH3:12][C:13]1[CH:18]=[CH:17][C:16]([CH2:19][CH2:20][CH2:21][NH:22][CH2:10][CH:8]([OH:9])[C:4]2[CH:5]=[CH:6][CH:7]=[C:2]([Cl:1])[CH:3]=2)=[CH:15][CH:14]=1

Participants

3

Reactant 2

HCID 124638932-(3-Chlorophenyl)-2-oxoacetaldehydeHCID 125642703-(4-Methylphenyl)propan-1-amine

Product 1

HCID 23322149N-(3-(4-Methylphenyl)propyl)-2-hydroxy-2-(3-chlorophenyl)ethanamine

Procedure

The title compound was prepared in the manner described in Example 9 using 3-chlorophenylglyoxal and 3-(4-methylphenyl)propanamine. Recrystallisation of the chromatographed material from ether gave the title compound, mp 115°-117.5°.

Workup

  1. customThe title compound was prepared in the manner
  2. customRecrystallisation of the chromatographed material from ether

Sources & evidence

ORD record
ord-229e1f0bdef4444c9120f96e66be94cb
Source dataset
uspto-grants-1986_05
Patent number
US04588749

Reaction notes

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