反应详情

The thus formed solution of diphenylcarbamic acid chloride was then added dropwise upon stirring to a mixture of 114 g of cyclopropylamine, 202 g of triethylamine and 500 ml of toluene. During the addition the temperature inside the flask rose to 85° C. Subsequently the reaction mass was heated to boiling point for 15 minutes and then cooled. The precipitated triethylammoniumchloride was removed by suction and the solvent was distilled off in a vacuum. The remaining residue was subjected to recrystallization from diisopropylether. The yield in 1-cyclopropyl-3,3-diphenylurea was 440.2 g (87.2% of the theoretical value). The melting point was 98° C.

1. additionDuring the addition the temperature inside the flask
2. customrose to 85° C
3. temperatureSubsequently the reaction mass was heated
4. customfor 15 minutes
5. temperaturecooled
6. customThe precipitated triethylammoniumchloride was removed by suction
7. distillationthe solvent was distilled off in a vacuum
8. customThe remaining residue was subjected to recrystallization from diisopropylether
9. customThe yield in 1-cyclopropyl-3,3-diphenylurea