Sodium Iodide → HCID 66600966, compound

Participants

Reaction Steps

A mixture of 4.7 parts of 1-(2-chloroethyl)-4-methoxybenzene, 14 parts of N-(4-piperidinyl)-1-(4-thiazolylmethyl)-1H-benzimidazol-2-amine dihydrobromide.monohydrate, 15 parts of sodium carbonate, 0.3 parts of sodium iodide and 90 parts of N,N-dimethylacetamide was stirred overnight at 80° C. Water was added and the product was extracted with 4-methyl-2-pentanone. The extract was dried, filtered and evaporated. The oily residue was converted into the hydrobromide salt in ethanol. The salt was filtered off and dried, yielding 9 parts of N-[1-[2-(4-methoxyphenyl)ethyl]-4-piperidinyl]-1-(4-thiazolyl)-methyl)-1H-benzimidazol-2-amine dihydrobromide. dihydrate; mp. 239.2° C. (compound 17).

Provenance & Evidence