Sodium Iodide → HCID 66600966, compound

HRID 280339Notes

Reaction equation

HRID 280339 reaction equation
ClCCC1C=CC(OC)=CC=1.[BrH:12].Br.N1CCC([NH:20][C:21]2[N:25](CC3N=CSC=3)[C:24]3[CH:32]=[CH:33][CH:34]=[CH:35][C:23]=3[N:22]=2)CC1.C(=O)([O-])[O-].[Na+].[Na+].[I-].[Na+]>O.CN(C)C(=O)C>[BrH:12].[BrH:12].[NH:22]1[C:23]2[CH:35]=[CH:34][CH:33]=[CH:32][C:24]=2[N:25]=[C:21]1[NH2:20]

Participants

7

Reactant 4

HCID 5238Sodium IodideHCID 10340Sodium CarbonateHCID 875134-(2-Chloroethyl)phenyl methyl etherHCID 86740786HCID 86740786, compound

Product 1

HCID 66600966HCID 66600966, compound

Reagents, catalysts & solvents 2

HCID 962WaterSolventHCID 31374DimethylacetamideSolvent

Procedure

A mixture of 4.7 parts of 1-(2-chloroethyl)-4-methoxybenzene, 14 parts of N-(4-piperidinyl)-1-(4-thiazolylmethyl)-1H-benzimidazol-2-amine dihydrobromide.monohydrate, 15 parts of sodium carbonate, 0.3 parts of sodium iodide and 90 parts of N,N-dimethylacetamide was stirred overnight at 80° C. Water was added and the product was extracted with 4-methyl-2-pentanone. The extract was dried, filtered and evaporated. The oily residue was converted into the hydrobromide salt in ethanol. The salt was filtered off and dried, yielding 9 parts of N-[1-[2-(4-methoxyphenyl)ethyl]-4-piperidinyl]-1-(4-thiazolyl)-methyl)-1H-benzimidazol-2-amine dihydrobromide. dihydrate; mp. 239.2° C. (compound 17).

Workup

  1. extractionthe product was extracted with 4-methyl-2-pentanone
  2. customThe extract was dried
  3. filtrationfiltered
  4. customevaporated
  5. filtrationThe salt was filtered off
  6. customdried

Sources & evidence

ORD record
ord-2a7f8d4a08004eaebad8b52c9e71c6e9
Source dataset
uspto-grants-1986_05
Patent number
US04588722

Reaction notes

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