反应详情

温度

0 °C

To a solution of lithium aluminum hydride (0.8 g) in 50 ml of tetrahydrofuran was added (2S-trans)-4-cyclohexyl-5-oxo-2-pyrrolidinemethanol (2.0 g) in 20 ml of tetrahydrofuran. After the addition, the mixture was refluxed for 24 hours, cooled to 0° C., quenched with ethyl acetate followed by saturated sodium sulphate solution, filtered, and the filtrate dried over anhydrous magnesium sulphate. Removal of the solvent followed by crystallization yielded 0.7 g of (2S-trans)-4-cyclohexyl-2-pyrrolidinemethanol as white crystals, melting point 98°-99° C.

1. additionAfter the addition
2. temperaturethe mixture was refluxed for 24 hours
3. customquenched with ethyl acetate
4. filtrationfiltered
5. dry with materialthe filtrate dried over anhydrous magnesium sulphate
6. customRemoval of the solvent
7. customfollowed by crystallization