Hydrochloric Acid → HCID 178483233, compound

HRID 280408Notes

Reaction equation

HRID 280408 reaction equation
[NH2:1][C:2]1[C:6]([NH:7][CH2:8][CH2:9][S:10][CH2:11][C:12]2[O:13][C:14]([CH2:17][N:18]([CH3:20])[CH3:19])=[CH:15][CH:16]=2)=[N:5]S(=O)[N:3]=1.[ClH:22]>CO>[OH2:13].[ClH:22].[ClH:22].[ClH:22].[CH3:20][N:18]([CH2:17][C:14]1[O:13][C:12]([CH2:11][S:10][CH2:9][CH2:8][NH:7][C:6](=[NH:5])[C:2](=[NH:1])[NH2:3])=[CH:16][CH:15]=1)[CH3:19]

Participants

4

Reactant 2

HCID 313Hydrochloric AcidHCID 5384819CHEMBL8982

Product 1

HCID 178483233HCID 178483233, compoundYield 52%

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

A suspension of 3-amino-4-{2-[(5-dimethylaminomethyl-2-furyl)methylthio]ethylamino}-1,2,5-thiadiazole 1-oxide (6.59 g; 20.0 mmoles) [prepared according to published United Kingdom Patent Application No. 2,067,987] in 200 mL of methanol was warmed slightly to achieve complete solution, then treated with 13.3 mL of concentrated HCl. After stirring at ambient temperature for 2.5 hours, the solution was concentrated and the residue was triturated with 70 mL of absolute ethanol. The crystals were collected by filtration and dried under vacuum to give 4.3 g (52%) of the title compound, m.p. 166°-169° C. (dec.).

Workup

  1. temperaturewas warmed slightly
  2. concentrationthe solution was concentrated
  3. customthe residue was triturated with 70 mL of absolute ethanol
  4. filtrationThe crystals were collected by filtration
  5. customdried under vacuum

Sources & evidence

ORD record
ord-6e72f9081b284c81a2fd746a0e9186a6
Source dataset
uspto-grants-1986_05
Patent number
US04588826

Reaction notes

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