Hydrochloric Acid → HCID 178478603, compound

HRID 280415Notes

Reaction equation

HRID 280415 reaction equation
[NH2:1][C:2]1[C:6]([NH:7][CH2:8][CH2:9][S:10][CH2:11][C:12]2[CH:16]=[C:15]([CH2:17][N:18]3[CH2:23][CH2:22][CH2:21][CH2:20][CH2:19]3)[S:14][CH:13]=2)=[N:5]S(=O)[N:3]=1.[ClH:25]>CO>[ClH:25].[ClH:25].[ClH:25].[N:18]1([CH2:17][C:15]2[S:14][CH:13]=[C:12]([CH2:11][S:10][CH2:9][CH2:8][NH:7][C:6](=[NH:5])[C:2](=[NH:1])[NH2:3])[CH:16]=2)[CH2:23][CH2:22][CH2:21][CH2:20][CH2:19]1

Participants

4

Reactant 2

HCID 313Hydrochloric AcidHCID 23312528HCID 23312528, compound

Product 1

HCID 178478603HCID 178478603, compoundYield 83%

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

A suspension of 3-amino-4-{2-[(5-piperidinomethyl-3-thienyl)methylthio]ethylamino}-1,2,5-thiadiazole 1-oxide (6.1 g; 15.8 mmoles) [prepared according to published United Kingdom Patent Application No. 2,067,987] in 80 ml of methanol was treated with 10.5 ml of concentrated HCl. After stirring at ambient temperature for 3 hours, the solution was concentrated and the residue triturated with 50 ml of 1-propanol, filtered and dried to give 5.86 g (83%) of product. A sample was recrystallized from methanol-acetone to give the title compound, mp 201°-214° C. (dec.).

Workup

  1. concentrationthe solution was concentrated
  2. customthe residue triturated with 50 ml of 1-propanol
  3. filtrationfiltered
  4. customdried

Sources & evidence

ORD record
ord-a42e5d5e3c774cba95be7063468b5a6d
Source dataset
uspto-grants-1986_05
Patent number
US04588826

Reaction notes

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