Diethyl Ether → HCID 54258967, compound

HRID 280435Notes

Reaction equation

HRID 280435 reaction equation
CO[NH:3][CH3:4].[N:5]([C:8]1[CH:23]=[CH:22][C:11]([O:12][C:13]2[CH:14]=[CH:15][C:16]3[S:20][N:19]=[CH:18][C:17]=3[CH:21]=2)=[CH:10][CH:9]=1)=[C:6]=[O:7].C([O:26][CH2:27]C)C>>[CH3:27][O:26][N:5]([C:8]1[CH:23]=[CH:22][C:11]([O:12][C:13]2[CH:14]=[CH:15][C:16]3[S:20][N:19]=[CH:18][C:17]=3[CH:21]=2)=[CH:10][CH:9]=1)[C:6]([NH:3][CH3:4])=[O:7]

Participants

4

Reactant 3

HCID 3283Diethyl EtherHCID 14232N,O-DimethylhydroxylamineHCID 132693995-(4-Isocyanatophenoxy)-1,2-benzothiazole

Product 1

HCID 54258967HCID 54258967, compoundYield 82%

Procedure

6.1 parts of N-methoxy-N-methylamine were added to a solution of 26.8 parts of 5-(4'-isocyanatophenoxy)-benzisothiazole in 300 parts of diethyl ether at from 20° to 30° C., the mixture was stirred for 12 hours at this temperature and then evaporated down, and the residue was triturated in about 50 parts of diethyl ether, isolated and dried. 26 g (82% of theory) of 5-(4'-(N-methoxy-N-methylaminocarbonylamino)-phenoxy)-benzisothiazole of melting point 108° C. were obtained.

Workup

  1. customevaporated down
  2. customthe residue was triturated in about 50 parts of diethyl ether
  3. customisolated
  4. customdried

Sources & evidence

ORD record
ord-0df38d2b8ecf40e09ef4a1a51bd7b446
Source dataset
uspto-grants-1986_05
Patent number
US04589910

Reaction notes

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