HuagongsheHuagongshe Chemistry Print Report · For research reference only
Toluene → HCID 13269415, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Toluene | HCID 1140 | — |
| Reactant | Methyl Isocyanate | HCID 12228 | — |
| Reactant | 4-[(1,2-Benzothiazol-5-yl)oxy]-3-(trifluoromethyl)aniline | HCID 13269402 | — |
| Solvent | Triethylamine | HCID 8471 | — |
| Product | HCID 13269415 | HCID 13269415 | 80% |
Reaction Steps
31 parts of 5-(4'-amino-2'-trifluoromethylphenoxy)-benzisothiazole, 400 parts of toluene, 1 part of triethylamine and 11.4 parts of methyl isocyanate were stirred for 12 hours at 80° C., after which the solvent was removed under reduced pressure and the residue was purified over silica gel, using chloroform as the mobile phase. 29.4 parts (80% of theory) of 5-(4'-methylaminocarbonylamino-2'-trifluoromethylphenoxy)-benzisothiazole of melting point 138° C. were obtained.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US04589910 |
| Source dataset | uspto-grants-1986_05 |
| ORD ID | ord-59db36452e1e405aa0ea4bf1981ac2cc |
| Source note | uspto-grants-1986_05 |