Hydrochloric Acid → HCID 13654126, compound

HRID 280456Notes

Reaction equation

HRID 280456 reaction equation
[C:1]([C:3]1[N:7]([C:8]2[CH:13]=[CH:12][CH:11]=[C:10]([C:14]#[N:15])[CH:9]=2)[N:6]=[CH:5][C:4]=1[C:16]([O:18]CC)=[O:17])#[N:2].[OH-].[K+].O.Cl>C(O)C>[C:1]([C:3]1[N:7]([C:8]2[CH:13]=[CH:12][CH:11]=[C:10]([C:14]#[N:15])[CH:9]=2)[N:6]=[CH:5][C:4]=1[C:16]([OH:18])=[O:17])#[N:2]

Participants

6

Reactant 4

HCID 313Hydrochloric AcidHCID 962Water2×HCID 14797Potassium HydroxideHCID 13654125HCID 13654125, compound

Product 1

HCID 13654126HCID 13654126, compoundYield 62.4%

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent2×

Procedure

Approximately 7.7 g of 5-cyano-1-(3-cyanophenyl)-1H-pyrazole-4-carboxylic acid, ethyl ester was dissolved in 75 ml of hot ethanol. To the reaction mixture was added 3.2 g of potassium hydroxide dissolved in ethanol. A small amount of water was added to the reaction mixture which was immediately poured into water. The solution was then acidified with concentrated hydrochloric acid and the precipitated solid was collected by filtration and dried to provide 4.3 g of 5-cyano-1-(3-cyanophenyl)-1H-pyrazole-4-carboxylic acid. MP=190°-192° C.

Workup

  1. filtrationthe precipitated solid was collected by filtration
  2. customdried

Sources & evidence

ORD record
ord-009d0408e47843a9bf2a8d1b1608a681
Source dataset
uspto-grants-1986_05
Patent number
US04589905

Reaction notes

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