反应详情

20 grams of Quinuclidine (1 Aza bicyclo [2.2.2]octane, Aldrich) were dissolved in 100 ml of chloroform with stirring and cooling in an ice bath. 28.08 Grams of ethyl iodide (Aldrich) were added dropwise. The mixture became cloudy and was stirred overnight, slowly coming to room temperature. Acetone was added to the solution and then, with stirring, diethyl ether was added dropwise until crystals formed. The filtered solids were washed with acetone and dried under vacuum. The product had the correct microanalysis for C, H, and N.

1. temperaturecooling in an ice bath
2. stirringwas stirred overnight
3. customslowly coming to room temperature
4. stirringwith stirring
5. customformed
6. washThe filtered solids were washed with acetone
7. customdried under vacuum