Hydrochloric Acid → HCID 23320846, compound

Participants

Reaction Steps

The butyloxycarbonylpiperazine benzisothiazole (0.012 mole) was taken up in warm absolute ethanol and acidified with ethanolic HCl (5 mole equiv.). The solution was stirred 30 minutes at 90°. The mixture was cooled and the solvent removed in vacuo. The crude solid was recrystallized from absolute EtOH affording 4-methoxy-1,2-benzisothiazol-3-yl-piperazine hydrochloride in 62% yield.

Provenance & Evidence