Hydrochloric Acid → HCID 23320846, compound

HRID 280533Notes

Reaction equation

HRID 280533 reaction equation
[S:1]1[C:5]2[CH:6]=[CH:7][CH:8]=[CH:9][C:4]=2[CH:3]=[N:2]1.C(OC([N:17]1[CH2:22][CH2:21][NH:20][CH2:19][CH2:18]1)=O)CCC.[ClH:23].[CH2:24]([OH:26])C>>[ClH:23].[CH3:24][O:26][C:9]1[C:4]2[C:3]([N:17]3[CH2:22][CH2:21][NH:20][CH2:19][CH2:18]3)=[N:2][S:1][C:5]=2[CH:6]=[CH:7][CH:8]=1

Participants

4

Reactant 3

HCID 313Hydrochloric AcidHCID 702EthanolHCID 70455347HCID 70455347, compound

Product 1

HCID 23320846HCID 23320846, compoundYield 62%

Procedure

The butyloxycarbonylpiperazine benzisothiazole (0.012 mole) was taken up in warm absolute ethanol and acidified with ethanolic HCl (5 mole equiv.). The solution was stirred 30 minutes at 90°. The mixture was cooled and the solvent removed in vacuo. The crude solid was recrystallized from absolute EtOH affording 4-methoxy-1,2-benzisothiazol-3-yl-piperazine hydrochloride in 62% yield.

Workup

  1. temperatureThe mixture was cooled
  2. customthe solvent removed in vacuo
  3. customThe crude solid was recrystallized from absolute EtOH

Sources & evidence

ORD record
ord-bcfa1f9037cc4d40b387facb1f56ad85
Source dataset
uspto-grants-1986_05
Patent number
US04590196

Reaction notes

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