反应详情

A solution of 2-(2-aminoethoxy)methyl-4-(2-chlorophenyl)-3-ethoxycarbonyl-5-methoxycarbonyl-6-methyl-1,4-dihydropyridine (0.82 g) and sulphamide (0.96 g) in dioxane (30 ml) was heated under reflux for 70 minutes and then evaporated. The residue was partitioned between ethyl acetate and water and the organic layer dried (Na2SO4) and evaporated. The residue was triturated with diethyl ether and the resulting solid collected, washed with diethyl ether and dried to give the title compound (0.75 g), m.p. 150°-152° C. Found: C, 49.33; H, 5.35; N, 8.93. C20H26ClN3O7S requires C, 49.23; H, 5.37; N, 8.61%.

1. temperatureunder reflux for 70 minutes
2. customevaporated
3. customThe residue was partitioned between ethyl acetate and water
4. dry with materialthe organic layer dried (Na2SO4)
5. customevaporated
6. customThe residue was triturated with diethyl ether
7. customthe resulting solid collected
8. washwashed with diethyl ether
9. customdried