Hydrochloric Acid → HCID 53739261, compound

HRID 280614Notes

Reaction equation

HRID 280614 reaction equation
[CH3:1][C:2]1[S:6][C:5]2[C:7]([C:11]([OH:13])=[O:12])=[CH:8][CH:9]=[CH:10][C:4]=2[CH:3]=1.Cl.[CH3:15]O>>[CH3:15][O:12][C:11]([C:7]1[C:5]2[S:6][C:2]([CH3:1])=[CH:3][C:4]=2[CH:10]=[CH:9][CH:8]=1)=[O:13]

Participants

4

Reactant 3

HCID 313Hydrochloric AcidHCID 887MethanolHCID 126239032-Methyl-1-benzothiophene-7-carboxylic acid

Product 1

HCID 53739261HCID 53739261, compound

Procedure

A solution of 2-methylbenzo[b]thiophene-7-carboxylic acid (5.1 g) in methanol (100 ml) was saturated with hydrogen chloride and then heated under reflux for 18 hours. The solution was evaporated and the residue was dissolved in ether. The ether solution was washed with sodium carbonate solution and dried (Na2SO4). Evaporation of the ether gave 2-methylbenzo[b]thiophene-7-carboxylic acid methyl ester (4.7 g), m.p. 48°-49°.

Workup

  1. temperatureheated
  2. temperatureunder reflux for 18 hours
  3. customThe solution was evaporated
  4. dissolutionthe residue was dissolved in ether
  5. washThe ether solution was washed with sodium carbonate solution
  6. dry with materialdried (Na2SO4)
  7. customEvaporation of the ether

Sources & evidence

ORD record
ord-6f87be024b13420eb8893aea4f40d0c7
Source dataset
uspto-grants-1986_05
Patent number
US04590200

Reaction notes

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